The Hoebe Laboratory is involved in deciphering the genetic basis of the host immune response using a forward genetic approach. The goal of our research is to identify critical genes or aberrations therein that predispose to immune-related diseases, including auto-immune diseases or primary immunodeficiencies. Dr. Hoebe has made several fundamental discoveries in the toll-like receptor (TLR) field, (Nature 424:743; Nature 433:523) and has made important contributions to the mechanistic understanding of connections between innate and adaptive immunity, focusing on the central question; “what drives optimal T cell activation during vaccination or disease.” This has resulted in a number of highly cited peer-reviewed publications reporting essential pathways involving not only microbial but also “sterile” inflammatory pathways leading to robust T cell activation (Nat Immunol. 4:1223-9; Immunity 24:787; Blood 113:6593).
Recently, work in the laboratory has focused on delineating the molecular pathways supporting regulatory T cell function and development (PLoS Biol. 2009 Mar 3;7(3):e51). Particularly the Hoebe Lab is committed to understanding the functional role of Gimap5 in lymphocytes and immunological tolerance (J Immunol. 184:3743-54; J Immunol. 188:146-54); a gene that is critical for T cell survival and peripheral tolerance, while its function remains poorly understood.