Cancelas Lab

Publications

Rubinstein, JD; Zhu, X; Leemhuis, T; Pham, G; Ray, L; Emberesh, S; Jodele, S; Thomas, S; Cancelas, JA; Bollard, CM; et al. Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted. Blood Advances. 2021; 5:3309-3321.

Fan, Y; Teng, Y; Loison, F; Pang, A; Kasorn, A; Shao, X; Zhang, C; Ren, Q; Yu, H; Zheng, Y; et al. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Science Translational Medicine. 2021; 13:eabb1069.

Adori, C; Daraio, T; Kuiper, R; Barde, S; Horvathova, L; Yoshitake, T; Ihnatko, R; Valladolid-Acebes, I; Vercruysse, P; Wellendorf, AM; et al. Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging. Science Advances. 2021; 7:eabg5733.

Serrano-Lopez, J; Hegde, S; Kumar, S; Serrano, J; Fang, J; Wellendorf, AM; Roche, PA; Rangel, Y; Carrington, LJ; Geiger, H; et al. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. eLife. 2021; 10:e66190.

Hegde, S; Wellendorf, AM; Zheng, Y; Cancelas, JA. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion. 2021; 61:557-567.

Golan, K; Singh, AK; Kollet, O; Bertagna, M; Althoff, MJ; Khatib-Massalha, E; Petrovich-Kopitman, E; Wellendorf, AM; Massalha, H; Levin-Zaidman, S; et al. Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma. Blood. 2020; 136:2607-2619.

Nelson, AS; Heyenbruch, D; Rubinstein, JD; Sabulski, A; Jodele, S; Thomas, S; Lutzko, C; Zhu, X; Leemhuis, T; Cancelas, JA; et al. Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients. Blood Advances. 2020; 4:5745-5754.

Govindarajah, V; Lee, JM; Solomon, M; Goddard, B; Nayak, R; Nattamai, K; Geiger, H; Salomonis, N; Cancelas, JA; Reynaud, D. FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia. Blood Advances. 2020; 4:5512-5526.

Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020; 136:1824-1836.

Kelly, K; Cancelas, JA; Szczepiorkowski, ZM; Dumont, DF; Rugg, N; Dumont, LJ. Frozen Platelets-Development and Future Directions. Transfusion Medicine Reviews. 2020; 34:286-293.

Vandenbroeke, T; Gloor, C; Wingfield, T; Leite, C; Carr, K; Turner, C; Ngamsuntikul, S; Sutor, L; Compton, F; Nestheide, S; et al. In vitro quality parameters of whole blood-derived platelets pooled using two different platelet pooling sets and stored up to 7 days are similar. Transfusion. 2024; 64:132-140.

Solomon, M; Song, B; Govindarajah, V; Good, S; Arasu, A; Hinton, EB; Thakkar, K; Bartram, J; Filippi, MD; Cancelas, JA; et al. Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions. The Journal of Experimental Medicine. 2024; 221:e20231035.

Singh, AK; Prasad, P; Cancelas, JA. Mesenchymal stromal cells, metabolism, and mitochondrial transfer in bone marrow normal and malignant hematopoiesis. Frontiers in Cell and Developmental Biology. 2023; 11:1325291.

Thant, M; Cancelas, J; Kaplan, A. The enhanced direct antiglobulin test in current practice has a limited impact on management of adult patients. Transfusion and Apheresis Science. 2023; 62:103768.

Galletta, TJ; Lane, A; Lutzko, C; Leemhuis, T; Cancelas, JA; Khoury, R; Wang, YZ M; Hanley, PJ; Keller, MD; Bollard, CM; et al. Third-Party and Patient-Specific Donor-Derived Virus-Specific T Cells Demonstrate Similar Efficacy and Safety for Management of Viral Infections after Hematopoietic Stem Cell Transplantation in Children and Young Adults. Transplantation and cellular therapy. 2023; 29:305-310.

Butler-Foster, T; Khandelwal, A; Montemayor, C; Miller, YM; Yan, MT S; Holmberg, JA; Ipe, TS; Accooe, P; Cancelas, JA. From MPOX to the next epidemic: Words matter when talking about equity-deserving groups. Transfusion. 2023; 63:646-651.

Dandamudi, A; Seibel, W; Tourdot, B; Cancelas, JA; Akbar, H; Zheng, Y. Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents. International Journal of Molecular Sciences. 2023; 24:4167.

Menéndez-Gutiérrez, MP; Porcuna, J; Nayak, R; Paredes, A; Niu, H; Núñez, V; Paranjpe, A; Gómez, MJ; Bhattacharjee, A; Schnell, DJ; et al. Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homeostasis. Blood. 2023; 141:592-608.

Dandamudi, A; Akbar, H; Cancelas, J; Zheng, Y. Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies. International Journal of Molecular Sciences. 2023; 24:2519.

Hegde, S; Nestheide, S; Wellndorf, A; Zheng, Y; Cancelas, J. 3080 – RHOA SIGNALING IS REQUIRED FOR THE COLD-INDUCED PLATELET LESION AND REVERSIBLE TARGETING OF RHOA IN A NEW PLATELET ADDITIVE SOLUTION EXTENDS DONOR-DERIVED PLATELET SHELF-LIFE TO FOURTEEN DAYS. Experimental Hematology. 2023; 124:s90.

Nayak, RC; Chang, KH; Singh, AK; Kotliar, M; Desai, M; Wellendorf, AM; Wunderlich, M; Bartram, J; Mizukawa, B; Cuadrado, M; et al. Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis. Nature Communications. 2022; 13:3056.

Noel, JG; Ramser, SW; Pitstick, L; Bonamer, JP; Mackenzie, B; Seu, KG; Kalfa, TA; Cancelas, JA; Gardner, JC. M-CSF supports medullary erythropoiesis and erythroid iron demand following burn injury through its activity on homeostatic iron recycling. Scientific Reports. 2022; 12:1235.

Solomon, M; Song, BA; Govindarajah, V; Good, S; Bartram, J; Cancelas, J; Filippi, M; Salomonis, N; Grimes, HL; Reynaud, D. Hematopoietic Flt3+ Multipotent Progenitors Are Organized in Discrete Functionally and Hierarchically Distinct Populations. Blood. 2022; 140:1981-1982.

Seu, K; Voulgaridou, A; Stewart, M; Meznarich, J; Johnson, C; Junge, H; Mackenzie, B; Blanc, L; Cancelas, JA; Kalfa, TA. Dominant-Negative VPS4A Mutations Causing Congenital Dyserythropoietic Anemia Disrupt Iron Trafficking of Terminal Erythropoiesis. Blood. 2022; 140:8190-8191.

Hegde, S; Zheng, Y; Cancelas, JA. Novel blood derived hemostatic agents for bleeding therapy and prophylaxis. Current Opinion in Hematology. 2022; 29:281-289.

Cancelas, JA. Precision transfusion medicine: a new spin. Blood. 2022; 140:1661-1663.

Cancelas, JA; Genthe, JR; Stolla, M; Rugg, N; Bailey, SL; Nestheide, S; Shaz, B; Mack, S; Schroeder, K; Anani, W; et al. Evaluation of amotosalen and UVA pathogen-reduced apheresis platelets after 7-day storage. Transfusion. 2022; 62:1619-1629.

Vogel, M; Möhrle, B; Sakk, V; Brown, A; Palmer, A; Braumüller, S; Huber-Lang, M; Allgöwer, A; Cancelas, JA; Geiger, H. A Limited Role for AMD3100 Induced Stem Cell Mobilization for Modulation of Thoracic Trauma Outcome. Shock. 2022; 57:260-267.

Rubinstein, JD; Lutzko, C; Leemhuis, T; Zhu, X; Pham, G; Ray, L; Thomas, S; Dourson, C; Wilhelm, J; Lane, A; et al. Scheduled administration of virus-specific T cells for viral prophylaxis after pediatric allogeneic stem cell transplant. Blood Advances. 2022; 6:2897-2907.

Mock, DM; Stowell, SR; Franco, RS; Kyosseva, SV; Nalbant, D; Schmidt, RL; Cress, GA; Strauss, RG; Cancelas, JA; von Goetz, M; et al. Antibodies against biotin-labeled red blood cells can shorten posttransfusion survival. Transfusion. 2022; 62:770-782.

Cram, JP; Wu, J; Coover, RA; Rizvi, TA; Chaney, KE; Ravindran, R; Cancelas, JA; Spinner, RJ; Ratner, N. P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis. eLife. 2022; 11:e73511.

Hegde, S; Gasilina, A; Wunderlich, M; Lin, Y; Buchholzer, M; Krumbach, OH F; Akbarzadeh, M; Ahmadian, MR; Seibel, W; Zheng, Y; et al. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia. 2022; 36:637-647.

Galletta, TJ; Lane, A; Lutzko, CM; Leemhuis, T; Cancelas, JA; Khoury, R; Wang, YM; Hanley, PJ; Keller, MD; Bollard, CM; et al. 477 Availability of Donor Derived Patient Specific Virus-Specific T-Cells (VSTs) Is Not Associated with Differences in Outcomes As Compared to Frontline Administration of Third Party Vsts for the Management of Viral Infections after Pediatric Hematopoietic Stem Cell Transplant. Transplantation and cellular therapy. 2022; 28:s374-s375.

Ohanian, M; Cancelas, JA; Davenport, R; Pullarkat, V; Hervig, T; Broome, C; Marek, K; Kelly, M; Gul, Z; Rugg, N; et al. Freeze-dried platelets are a promising alternative in bleeding thrombocytopenic patients with hematological malignancies. American Journal of Hematology. 2022; 97:256-266.

Rubinstein, JD; Jodele, S; Heyenbruch, D; Wilhelm, J; Thomas, S; Lutzko, C; Zhu, X; Leemhuis, T; Cancelas, JA; Keller, M; et al. Off-the-Shelf Third-Party Virus-Specific T Cell Therapy to Treat JC Polyomavirus Infection in Hematopoietic Stem Cell Transplantation Recipients. Transplantation and cellular therapy. 2022; 28:116.e1-116.e7.

Cancelas, JA; Nestheide, S; Rugg, N; Eckerman, A; Macdonald, VW; Charles, ML; Markstrom, L; Atkinson, AJ; King, MR; Snyder, M; et al. Characterization and first-in-human clinical dose-escalation safety evaluation of a next-gen human freeze-dried plasma. Transfusion. 2022; 62:406-417.

Rubinstein, JD; Zhu, X; Leemhuis, T; Pham, G; Ray, L; Emberesh, S; Jodele, S; Thomas, S; Cancelas, JA; Bollard, CM; et al. Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted. Blood Advances. 2021; 5:3309-3321.

Fan, Y; Teng, Y; Loison, F; Pang, A; Kasorn, A; Shao, X; Zhang, C; Ren, Q; Yu, H; Zheng, Y; et al. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Science Translational Medicine. 2021; 13:eabb1069.

Adori, C; Daraio, T; Kuiper, R; Barde, S; Horvathova, L; Yoshitake, T; Ihnatko, R; Valladolid-Acebes, I; Vercruysse, P; Wellendorf, AM; et al. Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging. Science Advances. 2021; 7:eabg5733.

Davis, G; York, AJ; Bacon, WC; Lin, SC; McNeal, MM; Yarawsky, AE; Maciag, JJ; Miller, JL C; Locker, KC S; Bailey, M; et al. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. Editor, Kumar B. PloS one. 2021; 16:e0254667.

Serrano-Lopez, J; Hegde, S; Kumar, S; Serrano, J; Fang, J; Wellendorf, AM; Roche, PA; Rangel, Y; Carrington, LJ; Geiger, H; et al. Systemic inflammation recruits fast-acting anti-inflammatory innate myeloid progenitors from BM into lymphatics. eLife. 2021; 10:1-60.

Serrano-Lopez, J; Hegde, S; Kumar, S; Serrano, J; Fang, J; Wellendorf, AM; Roche, PA; Rangel, Y; Carrington, LJ; Geiger, H; et al. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. eLife. 2021; 10:e66190.

Singh, AK; Cancelas, JA. Mitochondria Transfer in Bone Marrow Hematopoietic Activity. Current stem cell reports. 2021; 7:1-12.

Lipps, D; Zhu, X; Lutzko, C; Leemhuis, T; Cancelas, JA; Jodele, S; Keller, MD; Bollard, CM; Hanley, PJ; Rubinstein, JD; et al. 433 T Cell Co-Stimulatory Blockade By CTLA4-Ig Does Not Appear to Impact the Clinical Efficacy of Viral Specific T Cell Therapy in Pediatric Patients after HSCT. Transplantation and cellular therapy. 2021; 27:s357-s358.

Wang, YM; Lipps, D; Wilson, B; Leemhuis, T; Cancelas, JA; Lane, A; Badia, P; Davies, SM; Dandoy, CE. 180 Beware Cells That Come in the Night: Time of Stem Cell Infusion As Risk Factor for Primary Graft Failure. Transplantation and cellular therapy. 2021; 27:s166-s167.

Rubinstein, JD; Lutzko, C; Leemhuis, T; Zhu, X; Ray, L; Thomas, S; Dourson, C; Wilhelm, J; Lane, A; Cancelas, JA; et al. 91 Scheduled Donor-Derived Viral Specific T-Cells for Prophylaxis Against Double Stranded DNA Viral Infection after Pediatric Allogeneic Hematopoietic Stem Cell Transplantation. Transplantation and cellular therapy. 2021; 27:s87-s88.

Prus, K; Alquist, CR; Cancelas, JA; Oh, D. Decrease in serum antibodies to SARS-CoV-2 in convalescent plasma donors over time. Transfusion. 2021; 61:651-654.

Hegde, S; Wellendorf, AM; Zheng, Y; Cancelas, JA. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion. 2021; 61:557-567.

Golan, K; Singh, AK; Kollet, O; Bertagna, M; Althoff, MJ; Khatib-Massalha, E; Petrovich-Kopitman, E; Wellendorf, AM; Massalha, H; Levin-Zaidman, S; et al. Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma. Blood. 2020; 136:2607-2619.

Hegde, S; Cancelas, JA. Retrograde bacterial contamination as an artifact of platelet contamination investigations. 2020; 5:40.

Nelson, AS; Heyenbruch, D; Rubinstein, JD; Sabulski, A; Jodele, S; Thomas, S; Lutzko, C; Zhu, X; Leemhuis, T; Cancelas, JA; et al. Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients. Blood Advances. 2020; 4:5745-5754.

Govindarajah, V; Lee, JM; Solomon, M; Goddard, B; Nayak, R; Nattamai, K; Geiger, H; Salomonis, N; Cancelas, JA; Reynaud, D. FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia. Blood Advances. 2020; 4:5512-5526.

Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020; 136:1824-1836.

Kelly, K; Cancelas, JA; Szczepiorkowski, ZM; Dumont, DF; Rugg, N; Dumont, LJ. Frozen Platelets-Development and Future Directions. Transfusion Medicine Reviews. 2020; 34:286-293.

Boucher, AA; Luchtman-Jones, L; Palumbo, JS; Cancelas, JA; Abu-El-Haija, M; Jenkins, TM; Lin, TK; Nathan, JD. Extreme Thrombocytosis after Pediatric Pancreatectomy with Islet Autotransplantation Is Unique Compared to Other Postsplenectomy States. Journal of Pediatric Surgery. 2020; 55:1645-1650.

Rubinstein, JD; Zhu, X; Lutzko, C; Leemhuis, T; Cancelas, JA; Jodele, S; Bollard, CM; Hanley, PJ; Davies, SM; Grimley, MS; et al. Complement inhibition does not impair the clinical antiviral capabilities of virus-specific T-cell therapy. Blood Advances. 2020; 4:3252-3257.

D'Alessandro, A; Yoshida, T; Nestheide, S; Nemkov, T; Stocker, S; Stefanoni, D; Mohmoud, F; Rugg, N; Dunham, A; Cancelas, JA. Hypoxic storage of red blood cells improves metabolism and post-transfusion recovery. Transfusion. 2020; 60:786-798.

Gasilina, A; Premnauth, G; Gurjar, P; Biesiada, J; Hegde, S; Milewski, D; Ma, G; Kalin, TV; Merino, E; Meller, J; et al. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. Editor, Lebedeva IV. PloS one. 2020; 15:e0229801.

Yazer, MH; Spinella, PC; Doyle, L; Kaufman, RM; Dunn, R; Hess, JR; Filho, LA; Fontaine, M; Gathof, B; Jackson, B; et al. Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings. Anesthesiology. 2020; 132:525-534.

Singh, AK; Cancelas, JA. Gap Junctions in the Bone Marrow Lympho-Hematopoietic Stem Cell Niche, Leukemia Progression, and Chemoresistance. International Journal of Molecular Sciences. 2020; 21:E796.

Yu, Y; Choi, K; Wu, J; Andreassen, PR; Dexheimer, PJ; Keddache, M; Brems, H; Spinner, RJ; Cancelas, JA; Martin, LJ; et al. NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation. Acta Neuropathologica. 2020; 139:157-174.