Publications

Rubinstein, JD; Zhu, X; Leemhuis, T; Pham, G; Ray, L; Emberesh, S; Jodele, S; Thomas, S; Cancelas, JA; Bollard, CM; et al. Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted. Blood Advances. 2021; 5:3309-3321.

Fan, Y; Teng, Y; Loison, F; Pang, A; Kasorn, A; Shao, X; Zhang, C; Ren, Q; Yu, H; Zheng, Y; et al. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Science Translational Medicine. 2021; 13.

Adori, C; Daraio, T; Kuiper, R; Barde, S; Horvathova, L; Yoshitake, T; Ihnatko, R; Valladolid-Acebes, I; Vercruysse, P; Wellendorf, AM; et al. Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging. Science advances. 2021; 7.

Serrano-Lopez, J; Hegde, S; Kumar, S; Serrano, J; Fang, J; Wellendorf, AM; Roche, PA; Rangel, Y; Carrington, LJ; Geiger, H; et al. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. eLife. 2021; 10.

Hegde, S; Wellendorf, AM; Zheng, Y; Cancelas, JA. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion. 2021; 61:557-567.

Golan, K; Singh, AK; Kollet, O; Bertagna, M; Althoff, MJ; Khatib-Massalha, E; Petrovich-Kopitman, E; Wellendorf, AM; Massalha, H; Levin-Zaidman, S; et al. Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma. Blood. 2020; 136:2607-2619.

Nelson, AS; Heyenbruch, D; Rubinstein, JD; Sabulski, A; Jodele, S; Thomas, S; Lutzko, C; Zhu, X; Leemhuis, T; Cancelas, JA; et al. Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients. Blood Advances. 2020; 4:5745-5754.

Govindarajah, V; Lee, JM; Solomon, M; Goddard, B; Nayak, R; Nattamai, K; Geiger, H; Salomonis, N; Cancelas, JA; Reynaud, D. FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia. Blood Advances. 2020; 4:5512-5526.

Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020; 136:1824-1836.

Kelly, K; Cancelas, JA; Szczepiorkowski, ZM; Dumont, DF; Rugg, N; Dumont, LJ. Frozen Platelets-Development and Future Directions. Transfusion Medicine Reviews. 2020; 34:286-293.

Butler-Foster, T; Khandelwal, A; Montemayor, C; Miller, YM; Yan, MT S; Holmberg, JA; Ipe, TS; Accooe, P; Cancelas, JA. From MPOX to the next epidemic: Words matter when talking about equity-deserving groups. Transfusion. 2023; 63:646-651.

Dandamudi, A; Seibel, W; Tourdot, B; Cancelas, JA; Akbar, H; Zheng, Y. Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents. International Journal of Molecular Sciences. 2023; 24.

Menéndez-Gutiérrez, MP; Porcuna, J; Nayak, R; Paredes, A; Niu, H; Núñez, V; Paranjpe, A; Gómez, MJ; Bhattacharjee, A; Schnell, DJ; et al. Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homeostasis. Blood. 2023; 141:592-608.

Dandamudi, A; Akbar, H; Cancelas, J; Zheng, Y. Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies. International Journal of Molecular Sciences. 2023; 24.

Noel, JG; Ramser, SW; Pitstick, L; Bonamer, JP; Mackenzie, B; Seu, KG; Kalfa, TA; Cancelas, JA; Gardner, JC. M-CSF supports medullary erythropoiesis and erythroid iron demand following burn injury through its activity on homeostatic iron recycling. Scientific Reports. 2022; 12.

Nayak, RC; Chang, KH; Singh, AK; Kotliar, M; Desai, M; Wellendorf, AM; Wunderlich, M; Bartram, J; Mizukawa, B; Cuadrado, M; et al. Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis. Nature Communications. 2022; 13.

Seu, K; Voulgaridou, A; Stewart, M; Meznarich, J; Johnson, C; Junge, H; Mackenzie, B; Blanc, L; Cancelas, JA; Kalfa, TA. Dominant-Negative VPS4A Mutations Causing Congenital Dyserythropoietic Anemia Disrupt Iron Trafficking of Terminal Erythropoiesis. Blood. 2022; 140:8190-8191.

Solomon, M; Song, BA; Govindarajah, V; Good, S; Bartram, J; Cancelas, J; Filippi, M; Salomonis, N; Grimes, HL; Reynaud, D. Hematopoietic Flt3+ Multipotent Progenitors Are Organized in Discrete Functionally and Hierarchically Distinct Populations. Blood. 2022; 140:1981-1982.

Hegde, S; Zheng, Y; Cancelas, JA. Novel blood derived hemostatic agents for bleeding therapy and prophylaxis. Current Opinion in Hematology. 2022; 29:281-289.

Cancelas, JA. Precision transfusion medicine: a new spin. Blood. 2022; 140:1661-1663.

Cancelas, JA; Genthe, JR; Stolla, M; Rugg, N; Bailey, SL; Nestheide, S; Shaz, B; Mack, S; Schroeder, K; Anani, W; et al. Evaluation of amotosalen and UVA pathogen-reduced apheresis platelets after 7-day storage. Transfusion. 2022; 62:1619-1629.

Vogel, M; Möhrle, B; Sakk, V; Brown, A; Palmer, A; Braumüller, S; Huber-Lang, M; Allgöwer, A; Cancelas, JA; Geiger, H. A Limited Role for AMD3100 Induced Stem Cell Mobilization for Modulation of Thoracic Trauma Outcome. Shock. 2022; 57:260-267.

Rubinstein, JD; Lutzko, C; Leemhuis, T; Zhu, X; Pham, G; Ray, L; Thomas, S; Dourson, C; Wilhelm, J; Lane, A; et al. Scheduled administration of virus-specific T cells for viral prophylaxis after pediatric allogeneic stem cell transplant. Blood Advances. 2022; 6:2897-2907.

Mock, DM; Stowell, SR; Franco, RS; Kyosseva, SV; Nalbant, D; Schmidt, RL; Cress, GA; Strauss, RG; Cancelas, JA; von Goetz, M; et al. Antibodies against biotin-labeled red blood cells can shorten posttransfusion survival. Transfusion. 2022; 62:770-782.

Cram, JP; Wu, J; Coover, RA; Rizvi, TA; Chaney, KE; Ravindran, R; Cancelas, JA; Spinner, RJ; Ratner, N. P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis. eLife. 2022; 11.

Hegde, S; Gasilina, A; Wunderlich, M; Lin, Y; Buchholzer, M; Krumbach, OH F; Akbarzadeh, M; Ahmadian, MR; Seibel, W; Zheng, Y; et al. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia. 2022; 36:637-647.

Ohanian, M; Cancelas, JA; Davenport, R; Pullarkat, V; Hervig, T; Broome, C; Marek, K; Kelly, M; Gul, Z; Rugg, N; et al. Freeze-dried platelets are a promising alternative in bleeding thrombocytopenic patients with hematological malignancies. American Journal of Hematology. 2022; 97:256-266.

Rubinstein, JD; Jodele, S; Heyenbruch, D; Wilhelm, J; Thomas, S; Lutzko, C; Zhu, X; Leemhuis, T; Cancelas, JA; Keller, M; et al. Off-the-Shelf Third-Party Virus-Specific T Cell Therapy to Treat JC Polyomavirus Infection in Hematopoietic Stem Cell Transplantation Recipients. Transplantation and cellular therapy. 2022; 28:116.e1-116.e7.

Cancelas, JA; Nestheide, S; Rugg, N; Eckerman, A; Macdonald, VW; Charles, ML; Markstrom, L; Atkinson, AJ; King, MR; Snyder, M; et al. Characterization and first-in-human clinical dose-escalation safety evaluation of a next-gen human freeze-dried plasma. Transfusion. 2022; 62:406-417.

Rubinstein, JD; Zhu, X; Leemhuis, T; Pham, G; Ray, L; Emberesh, S; Jodele, S; Thomas, S; Cancelas, JA; Bollard, CM; et al. Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted. Blood Advances. 2021; 5:3309-3321.

Fan, Y; Teng, Y; Loison, F; Pang, A; Kasorn, A; Shao, X; Zhang, C; Ren, Q; Yu, H; Zheng, Y; et al. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Science Translational Medicine. 2021; 13.

Adori, C; Daraio, T; Kuiper, R; Barde, S; Horvathova, L; Yoshitake, T; Ihnatko, R; Valladolid-Acebes, I; Vercruysse, P; Wellendorf, AM; et al. Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging. Science advances. 2021; 7.

Davis, G; York, AJ; Bacon, WC; Lin, SC; McNeal, MM; Yarawsky, AE; Maciag, JJ; Miller, JL C; Locker, KC S; Bailey, M; et al. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. PLoS ONE. 2021; 16.

Serrano-Lopez, J; Hegde, S; Kumar, S; Serrano, J; Fang, J; Wellendorf, AM; Roche, PA; Rangel, Y; Carrington, LJ; Geiger, H; et al. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. eLife. 2021; 10.

Serrano-Lopez, J; Hegde, S; Kumar, S; Serrano, J; Fang, J; Wellendorf, AM; Roche, PA; Rangel, Y; Carrington, LJ; Geiger, H; et al. Systemic inflammation recruits fast-acting anti-inflammatory innate myeloid progenitors from BM into lymphatics. eLife. 2021; 10:1-60.

Singh, AK; Cancelas, JA. Mitochondria Transfer in Bone Marrow Hematopoietic Activity. Current stem cell reports. 2021; 7:1-12.

Prus, K; Alquist, CR; Cancelas, JA; Oh, D. Decrease in serum antibodies to SARS-CoV-2 in convalescent plasma donors over time. Transfusion. 2021; 61:651-654.

Hegde, S; Wellendorf, AM; Zheng, Y; Cancelas, JA. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion. 2021; 61:557-567.

Golan, K; Singh, AK; Kollet, O; Bertagna, M; Althoff, MJ; Khatib-Massalha, E; Petrovich-Kopitman, E; Wellendorf, AM; Massalha, H; Levin-Zaidman, S; et al. Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma. Blood. 2020; 136:2607-2619.

Hegde, S; Cancelas, JA. Retrograde bacterial contamination as an artifact of platelet contamination investigations. 2020; 5:40-40.

Nelson, AS; Heyenbruch, D; Rubinstein, JD; Sabulski, A; Jodele, S; Thomas, S; Lutzko, C; Zhu, X; Leemhuis, T; Cancelas, JA; et al. Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients. Blood Advances. 2020; 4:5745-5754.

Govindarajah, V; Lee, JM; Solomon, M; Goddard, B; Nayak, R; Nattamai, K; Geiger, H; Salomonis, N; Cancelas, JA; Reynaud, D. FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia. Blood Advances. 2020; 4:5512-5526.

Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020; 136:1824-1836.

Kelly, K; Cancelas, JA; Szczepiorkowski, ZM; Dumont, DF; Rugg, N; Dumont, LJ. Frozen Platelets-Development and Future Directions. Transfusion Medicine Reviews. 2020; 34:286-293.

Boucher, AA; Luchtman-Jones, L; Palumbo, JS; Cancelas, JA; Abu-El-Haija, M; Jenkins, TM; Lin, TK; Nathan, JD. Extreme Thrombocytosis after Pediatric Pancreatectomy with Islet Autotransplantation Is Unique Compared to Other Postsplenectomy States. Journal of Pediatric Surgery. 2020; 55:1645-1650.

Rubinstein, JD; Zhu, X; Lutzko, C; Leemhuis, T; Cancelas, JA; Jodele, S; Bollard, CM; Hanley, PJ; Davies, SM; Grimley, MS; et al. Complement inhibition does not impair the clinical antiviral capabilities of virus-specific T-cell therapy. Blood Advances. 2020; 4:3252-3257.

D'Alessandro, A; Yoshida, T; Nestheide, S; Nemkov, T; Stocker, S; Stefanoni, D; Mohmoud, F; Rugg, N; Dunham, A; Cancelas, JA. Hypoxic storage of red blood cells improves metabolism and post-transfusion recovery. Transfusion. 2020; 60:786-798.

Gasilina, A; Premnauth, G; Gurjar, P; Biesiada, J; Hegde, S; Milewski, D; Ma, G; Kalin, TV; Merino, E; Meller, J; et al. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. PLoS ONE. 2020; 15.

Yazer, MH; Spinella, PC; Doyle, L; Kaufman, RM; Dunn, R; Hess, JR; Filho, LA; Fontaine, M; Gathof, B; Jackson, B; et al. Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings. Anesthesiology. 2020; 132:525-534.

Singh, AK; Cancelas, JA. Gap Junctions in the Bone Marrow Lympho-Hematopoietic Stem Cell Niche, Leukemia Progression, and Chemoresistance. International Journal of Molecular Sciences. 2020; 21.

Yu, Y; Choi, K; Wu, J; Andreassen, PR; Dexheimer, PJ; Keddache, M; Brems, H; Spinner, RJ; Cancelas, JA; Martin, LJ; et al. NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation. Acta Neuropathologica. 2020; 139:157-174.

Nayak, RC; Hegde, S; Althoff, MJ; Wellendorf, AM; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, MT; et al. The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors. Nature Communications. 2019; 10.

Nassar, N; Hegde, SN; Gasilina, A; Wunderlich, M; Premnauth, G; Merino, E; Lin, Y; Ahmadian, R; Zheng, Y; Mizukawa, B; et al. The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph+(BCR-ABL1) B-ALL. Blood. 2019; 134:4647-4647.

Govindarajah, V; Lee, J; Solomon, M; Goddard, B; Nayak, RC; Cancelas, JA; Reynaud, D. Disruption of the Akt-FoxO Axis As a Safeguard Mechanism for the Hematopoietic Stem Cell Compartment during Chronic Metabolic Stress. Blood. 2019; 134:1201-1201.

Nayak, RC; Cancelas, JA. Ubiquitination is not omnipresent in myeloid leukemia. Haematologica. 2019; 104:1694-1696.

Atreya, C; Glynn, S; Busch, M; Kleinman, S; Snyder, E; Rutter, S; AuBuchon, J; Flegel, W; Reeve, D; Devine, D; et al. Proceedings of the Food and Drug Administration public workshop on pathogen reduction technologies for blood safety 2018 (Commentary, p. 3026). Transfusion. 2019; 59:3002-3025.

Trump, LR; Nayak, RC; Singh, AK; Emberesh, S; Wellendorf, AM; Lutzko, CM; Cancelas, JA. Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo. Stem cells translational medicine. 2019; 8:557-567.

Gasilina, A; Premnauth, G; Gurjar, P; Biesiada, J; Hegde, S; Milewski, D; Ma, G; Kalin, TV; Merino, E; Meller, J; et al. IODVA1, a Guanidinobenzimidazole Derivative with in vivo Activity Against Ras-Driven Cancer Models. 2019.

Cancelas, JA. Future of platelet formulations with improved clotting profile: a short review on human safety and efficacy data. Transfusion. 2019; 59:1467-1473.

Contact Us

Jose A. Cancelas Perez, MD, PhD

Mailing Address:
3333 Burnet Ave.
Cincinnati, OH 45229

Phone: 513-803-0939
Email: jose.cancelas@cchmc.org