Hegde Lab

Abe, H; Alavattam, KG; Hu, Y; Pang, Q; Andreassen, PR; Hegde, RS; Namekawa, SH. The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Current Biology. 2020; 30:408-420.e5.

Wang, Y; Pandey, RN; York, AJ; Mallela, J; Nichols, WC; Hu, Y; Molkentin, JD; Wikenheiser-Brokamp, KA; Hegde, RS. The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension. Nature Communications. 2019; 10.

Nguyen, MT; Vemaraju, S; Nayak, G; Odaka, Y; Buhr, ED; Alonzo, N; Tran, U; Batie, M; Upton, BA; Darvas, M; et al. An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye. Nature Cell Biology. 2019; 21:420-429.

Wang, Y; Pandey, RN; Riffle, S; Chintala, H; Wikenheiser-Brokamp, KA; Hegde, RS. The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth. Molecular Cancer Therapeutics. 2018; 17:1659-1669.

Riffle, S; Pandey, RN; Albert, M; Hegde, RS. Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids. BMC Cancer. 2017; 17.

Wang, Y; Tadjuidje, E; Pandey, RN; III, SJ A; Smith, LE H; Lang, RA; Hegde, RS. The Eyes Absent Proteins in Developmental and Pathological Angiogenesis. The American journal of pathology. 2016; 186:568-578.

Tadjuidje, E; Hegde, RS. The Eyes Absent proteins in development and disease. Cellular and Molecular Life Sciences. 2013; 70:1897-1913.

Rao, S; Chun, C; Fan, J; Kofron, JM; Yang, MB; Hegde, RS; Ferrara, N; Copenhagen, DR; Lang, RA. A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature. 2013; 494:243-246.

Tadjuidje, E; Sen Wang, T; Pandey, RN; Sumanas, S; Lang, RA; Hegde, RS. The EYA Tyrosine Phosphatase Activity Is Pro-Angiogenic and Is Inhibited by Benzbromarone. PLoS ONE. 2012; 7:e34806-e34806.

Pandey, RN; Rani, R; Yeo, E; Spencer, M; Hu, S; Lang, RA; Hegde, RS. The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells. Oncogene: Including Oncogene Reviews. 2010; 29:3715-3722.

Rayapureddi, JP; Kattamuri, C; Steinmetz, BD; Frankfort, BJ; Ostrin, EJ; Mardon, G; Hegde, RS. Eyes absent represents a class of protein tyrosine phosphatases. Nature. 2003; 426:295-298.

Hegde, RS; Roychoudhury, K; Pandey, RN. The multi-functional eyes absent proteins. Critical Reviews in Biochemistry and Molecular Biology (Informa). 2020; 55:372-385.

Abe, H; Alavattam, KG; Hu, Y; Pang, Q; Andreassen, PR; Hegde, RS; Namekawa, SH. The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Current Biology. 2020; 30:408-420.e5.

Wang, Y; Pandey, RN; York, AJ; Mallela, J; Nichols, WC; Hu, Y; Molkentin, JD; Wikenheiser-Brokamp, KA; Hegde, RS. The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension. Nature Communications. 2019; 10.

Nguyen, MT; Vemaraju, S; Nayak, G; Odaka, Y; Buhr, ED; Alonzo, N; Tran, U; Batie, M; Upton, BA; Darvas, M; et al. An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye. Nature Cell Biology. 2019; 21:420-429.

Wang, Y; Pandey, RN; Riffle, S; Chintala, H; Wikenheiser-Brokamp, KA; Hegde, RS. The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth. Molecular Cancer Therapeutics. 2018; 17:1659-1669.

Riffle, S; Pandey, RN; Albert, M; Hegde, RS. Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids. BMC Cancer. 2017; 17.

Riffle, S; Hegde, RS. Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids. Journal of Experimental and Clinical Cancer Research. 2017; 36.

Baltrunaite, K; Craig, MP; Desai, SP; Chaturvedi, P; Pandey, RN; Hegde, RS; Sumanas, S. ETS transcription factors Etv2 and Fli1b are required for tumor angiogenesis. Angiogenesis. 2017; 20:307-323.

Seco, CZ; Giese, AP; Shafique, S; Schraders, M; Oonk, AM M; Grossheim, M; Oostrik, J; Strom, T; Hegde, R; van Wijk, E; et al. Novel and recurrent CIB2 variants, associated with nonsyndromic deafness, do not affect calcium buffering and localization in hair cells. European Journal of Human Genetics. 2016; 24:542-549.

Wang, Y; Tadjuidje, E; Pandey, RN; III, SJ A; Smith, LE H; Lang, RA; Hegde, RS. The Eyes Absent Proteins in Developmental and Pathological Angiogenesis. The American journal of pathology. 2016; 186:568-578.